What is low substituted hydroxypropyl cellulose?

Low substituted hydroxypropyl cellulose, also commonly known as hydroxypropyl methycellulose (HPMC) or hypromellose is a binder and disintegrant inactive ingredient for solid dose forms in the pharmaceutical industry. It has also been used as a rate-controlling polymer for sustained-release dose forms.

What does hydroxypropyl cellulose do?

Hydroxypropyl cellulose is a thickener, suspending agent, film former, stabilizer, emulsifier, emollient, binders or water-retention agents. The ingredient is good a helping films form, has heat-sealing properties and is useful as an emulsifier and thickener in oil-in-water emulsions.

What is HPC?

(Low-substituted hydroxypropylcellulose) L-HPC is used as a binder and a disintegrant for solid dosage forms. It was brought onto the market in 1977, and then listed in the JP in 1986, in the NF in 1990 and in the EP in 2016. This product exhibits a wide range of compatibility with many active substances.

What is hydroxypropyl cellulose derived from?

wood cellulose
It is derived from wood cellulose by partial etherification with hydroxypropyl groups. Hydroxypropyl cellulose is in the form of white or yellowish-white granules or powder and is soluble in cold water, in ethanol (96%) and in propylene glycol giving colloidal solutions, practically insoluble in hot water.

What is the function of microcrystalline cellulose?

Microcrystalline cellulose, according to many publications, is an excipient most widely used for direct compression. Besides, it also serves as a strong dry binder, tablet disintegrant, absorbent, filler or diluent, a lubricant, and anti-adherent.

How do you make hydroxypropyl cellulose?

It is manufactured by reacting alkali cellulose with propylene oxide at elevated pressure and temperature to yield a highly substituted cellulose ether, with 3.4–4.1 mol of hydroxypropyl substituent per mole of anhydroglucose backbone units (Ashland, 2001).

What are the side effects of hydroxypropyl?

Side Effects

• Blurred vision.
• eye redness or discomfort or other irritation not present before use of this medicine.
• increased sensitivity of eyes to light.
• matting or stickiness of eyelashes.
• swelling of eyelids.
• watering of eyes.

Why is HPC needed?

Why is HPC important? It is through data that groundbreaking scientific discoveries are made, game-changing innovations are fueled, and quality of life is improved for billions of people around the globe. HPC is the foundation for scientific, industrial, and societal advancements.

Where is HPC used?

High-performance computing (HPC) is used in applications such as oil exploration, drug development, weather prediction, and for other scientific computing needs.

Is hydroxypropyl cellulose natural?

Hydroxypropyl methylcellulose (HPMC), also known as hypromellose, is produced from cellulose, a natural polymer and fiber, which is considered to be safe for human consumption. HPMC undergoes a rigorous manufacturing process involving the synthetic — and not natural — alteration of cellulose.

What are the side effects of cellulose?

SIDE EFFECTS: Eye discomfort/irritation/redness, tearing, eye sensitivity to light, sticky eyelashes, or temporary blurred vision may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

What is the difference between MCC 101 and 102?

MCC is commercially available in different particle sizes, density, and moisture grades that have different properties and applications. Avicel PH 101 is the original grade of MCC, while PH 102 is available as a partially agglomerated product with a larger particle size distribution and slightly better fluidity.

Who is the author of low substituted hydroxypropyl cellulose?

The Low-Substituted Hydroxypropyl Cellulose monograph will be incorporated into and become official with the USP 42–NF 37. Should you have any questions about the Low-Substituted Hydroxypropyl Cellulose monograph, please contact Dr. Tong (Jenny) Liu (240-221-2072 or [email protected] ).

Which is the hydroxypropyl group in cellulose?

HPC is an ether of cellulose in which some of the hydroxyl groups in the repeating glucose units have been hydroxypropylated forming -OCH2CH(OH)CH3 groups using propylene oxide.

Is the USP 42 for hydroxypropyl cellulose official?

Additionally, the monograph has been edited to be consistent with the current USP style. The Low-Substituted Hydroxypropyl Cellulose monograph will be incorporated into and become official with the USP 42–NF 37.

What is the degree of substitution for hydroxypropyl?

The average number of substituted hydroxyl groups per glucose unit is referred to as the degree of substitution (DS). Complete substitution would provide a DS of 3. Because the hydroxypropyl group added contains a hydroxyl group, this can also be etherified during preparation of HPC.