What is cord factor in Mycobacterium tuberculosis?

What is cord factor in Mycobacterium tuberculosis?

Cord factor, or trehalose dimycolate, is a glycolipid molecule found in the cell wall of Mycobacterium tuberculosis and similar species. It is the primary lipid found on the exterior of M. tuberculosis cells. Cord factor influences the arrangement of M.

What is the mechanism of Mycobacterium tuberculosis?

M. tuberculosis is transmitted through the air, not by surface contact. Transmission occurs when a person inhales droplet nuclei containing M. tuberculosis, and the droplet nuclei traverse the mouth or nasal passages, upper respiratory tract, and bronchi to reach the alveoli of the lungs (Figure 2.2).

What component of Mycobacterium tuberculosis makes it resistant to dessication?

We found that TDM imparts to membranes a striking resistance to desiccation; even membranes composed of a 1:3 molar ratio of glycolipid/phospholipids can be dehydrated and rehydrated without significant loss of membrane integrity and functionality.

What is cording Why do you see it in mycobacteria?

The aggregation of mycobacterial cells in a definite order, forming microscopic structures that resemble cords, is known as cord formation, or cording, and is considered a virulence factor in the Mycobacterium tuberculosis complex and the species Mycobacterium marinum.

What is the virulence factor of Mycobacterium tuberculosis?

PDIM and PLG are major virulence factors of mycobacteria. PDIM and PGL are molecules required for bacterial duplication during the acute phase [33].

What drugs are Mycobacterium tuberculosis resistant to?

Extensively drug-resistant TB (XDR TB) is a rare type of MDR TB that is resistant to isoniazid and rifampin, plus any fluoroquinolone and at least one of three injectable second-line drugs (i.e., amikacin, kanamycin, or capreomycin). Treating and curing drug-resistant TB is complicated.

How is Mycobacterium tuberculosis detected?

The Mantoux tuberculin skin test (TST) or the TB blood test can be used to test for M. tuberculosis infection. Additional tests are required to confirm TB disease. The Mantoux tuberculin skin test is performed by injecting a small amount of fluid called tuberculin into the skin in the lower part of the arm.