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What were the major findings in the crash 2 trial?

What were the major findings in the crash 2 trial?

Main outcome measures: The primary outcome was death in hospital within 4 weeks of injury, and was described with the following categories: bleeding, vascular occlusion (myocardial infarction, stroke and pulmonary embolism), multiorgan failure, head injury and other.

Does TXA cause DIC?

By inhibiting fibrinolysis, TXA might increase the risk of DIC. Although the underlying pathology in DIC is thrombosis, due to the consumption of coagulation factors DIC often manifests as bleeding.

Why is TXA harmful after 3 hours?

After 3 hours, TXA may do more harm than good 03; NNT = 77). TXA administered more than 3 hours after injury, however, appeared to increase the risk of death due to bleeding, to 4.4% compared with 3.1% for the placebo group (RR = 1.44; 95% CI, 1.12-1.84; P = . 004; number needed to harm = 77).

Does TXA prevent DIC?

TXA works by irreversibly blocking lysine-binding sites on plasminogen, thus preventing its conversion to plasmin and inhibiting fibrinolysis [24]. TXA use in DIC is controversial, and it must be used with extreme caution in DIC, as there is a risk of inducing microembolisms.

What is the crash 3 trial?

The CRASH-3 trial is an international, multicenter, pragmatic, randomized, double-blind, placebo-controlled trial to quantify the effects of the early administration of TXA on death and disability in patients with traumatic brain injury.

What is the crash trial?

CRASH is a large simple, placebo-controlled trial of the effects of a 48-hour infusion of corticosteroids on death and on neurological disability, among adults with head injury and some impairment of consciousness.

When should you not give TXA?

It recommends the administration of TXA to trauma patients who are bleeding or at risk of significant hemorrhaging as early as possible (GRADE 1A) and to bleeding trauma patients within 3 h after an injury (GRADE 1B). On the other hand, it recommends that TXA not be given after more than 3 h following an injury.

What is considered a massive blood transfusion?

Massive transfusion, historically defined as the replacement by transfusion of 10 units of red cells in 24 hours, is a treatment for massive and uncontrolled hemorrhage.

Can tranexamic acid cause death?

Our study found that the risk of death from head injury was reduced in patients treated with tranexamic acid, particularly when patients who had a Glasgow Coma Scale score of 3 and those with bilateral unreactive pupils at baseline were excluded. We found no evidence of any increase in disability among survivors.

When do you give trauma TXA?