How is the synthesis of aspirin carried out?

How is the synthesis of aspirin carried out?

The synthesis of aspirin may be achieved in one simple step, O-acetylation of salicylic acid (Figure 1), which is incorporated into many undergraduate synthetic chemistry laboratory courses. The purity of the product as a pharmaceutical is crucial, and Objectives

How to synthesize aspirin with ferric chloride?

1 Label three test tubes; place a few crystals of salicylic acid into test tube #1, a small sample of your aspirin… 2 Add 10 drops of 1% ferric chloride to each test tube. 3 Compare and record your observations.

Can a crystalline aspirin dissolve in cold water?

Some of the other compounds, acetic anhydride and acetic acid, dissolve in water, but salicylic acid is only slightly soluble in cold water. Vacuum filtration will separate the crystalline aspirin away from everything else in the reaction mixture except for any salicylic acid that did not react.

How can aspirin be made from acetic acid?

Aspirin can be made by reacting salicylic acid with acetic acid in the presence of an acid catalyst. The phenol group on the salicylic acid forms an ester with the carboxyl group on the acetic acid. However, this reaction is slow and has a relatively low yield.

How are hard aspirin tablets made and how are they made?

Raw Materials To produce hard aspirin tablets, corn starch and water are added to the active ingredient (acetylsalicylic acid) to serve as both a binding agent and filler, along with a lubricant. Binding agents assist in holding the tablets together; fillers (diluents) give the tablets increased bulk to produce tablets of adequate size.

How does aspirin prevent the growth of inflammation?

Since then, scientists have made further progress in understanding how aspirin works. They now know, for instance, that aspirin and its relatives actually prevent the growth of cells that cause inflammation.

Where was the active ingredient in aspirin found?

The compound from which the active ingredient in aspirin was first derived, salicylic acid, was found in the bark of a willow tree in 1763 by Reverend Edmund Stone of Chipping-Norton, England.

What’s the name of the company that makes aspirin?

Anthony (2002). It is used to treat mainly minor pains, but has their benefits like lowering fever, inflammation, and reduces blood from clotting. The trade name of aspirin is Bayer and the chemical name is acetylsalicylic acid. The manufacture name is time cap laboratories Inc that produces aspirin.

How does aspirin work as an antiinflammatory agent?

Aspirin is an orally administered non-steroidal antiinflammatory agent. Acetylsalicylic acid binds to and acetylates serine residues in cyclooxygenases, resulting in decreased synthesis of prostaglandin, platelet aggregation, and inflammation. This agent exhibits analgesic, antipyretic, and anticoagulant properties.

What kind of chemical is an aspirin suppository?

Aspirin is classified as a non-selective cyclooxygenase (COX) inhibitor and is available in many doses and forms, including chewable tablets, suppositories, extended release formulations, and others. Acetylsalicylic acid is a very common cause of accidental poisoning in young children.