How does FGFR2 work?

The FGFR2 protein plays an important role in bone growth, particularly during development before birth (embryonic development). For example, this protein signals certain immature cells in the developing embryo to become bone cells and form the head, hands, feet, and other tissues.

What is the FGFR2 gene?

Listen to pronunciation. (… jeen) A gene that makes a protein that is involved in cell division, cell maturation, formation of new blood vessels, wound healing, and bone growth and development.

What cells express FGFR2?

As determined by in situ hybridization, both FGFR2 IIIb and FGF7 mRNA are expressed in CRC cells, and FGF7 mRNA was recognized in neuroendocrine cells lying close to CRC cells [50].

Where is the FGFR2 gene located?

chromosome 10
Fibroblast growth factor receptor 2 (FGFR2) also known as CD332 (cluster of differentiation 332) is a protein that in humans is encoded by the FGFR2 gene residing on chromosome 10.

How many exons are in FGFR2?

FGFR2 gene, consisting of at least 21 exons, encodes multiple isoforms due to alternative splicing.

What does the FGFR3 gene do?

A gene that makes a protein that is involved in cell division, cell maturation, formation of new blood vessels, wound healing, and bone growth, development, and maintenance. A mutation (change) in the FGFR3 gene may cause the FGFR3 protein to become overactive in certain bone disorders, genetic conditions, and cancers.

How many exons does FGFR2 gene have?

21 exons
FGFR2 gene, consisting of at least 21 exons, encodes multiple isoforms due to alternative splicing.

Is Fgfr a gene?

The human fibroblast growth factor receptor (FGFR) family consists of four members: FGFR1 to FGFR4. Despite being encoded by separate genes, the four members share high homology, with their sequence identity varying from 56% to 71% [1].

Is FGFR3 a gene?

What are the effects of switching from FGFR2 to IIIC?

Studies indicate that switching from fibroblast growth factor receptor 2 (FDFR-2) IIIb to IIIc variants correlates with the aggressiveness of the cancers via epithelial-mesenchymal transition [Review]. These results unveil the complexity of ER regulation by FGFR2-mediated signaling likely to be associated with BCa resistance to endocrine therapy.

What is the function of the FGFR2 gene?

The FGFR2 gene provides instructions for making a protein called fibroblast growth factor receptor 2 (FGFR2).

What happens when FGFR2b is deactivated in bescs?

Inactivation of fibroblast growth factor receptor 2 (Fgfr2b) in bronchial epithelial stem cells (BESCs) impairs their contribution to both alveolar epithelial regeneration

How is FGFR2b signaling related to branching morphogenesis?

FGFR2c signaling regulates branching morphogenesis through the activation of FGFR2b signaling via increased FGF10 autocrine. These results provide new insight into the mechanisms by which crosstalk between FGFR2b and FGFR2c results in efficient branching morphogenesis.