How much volume can you give in a subcutaneous injection?

Administration into the subcutaneous (SC) tissue is a typical route of delivery for therapeutic proteins, especially for frequent treatments, long-term regimens, or self-administration. It is currently believed that the maximum volume for SC injections is approximately 1.5 mL.

When giving a subcutaneous injection you should give no more than how many mL?

Usually, no more than 1 ml of medication is given subcutaneously, as larger amounts may cause discomfort to the patient and may not be absorbed appropriately (Lynn, 2011).

Can you give 2ml subcutaneously?

Drugs administered by the subcutaneous route are deposited into subcutaneous tissue (Fig 1); small volumes (up to 2ml) of non-irritant, water-soluble drugs can be administered by subcutaneous injection (Dougherty and Lister, 2015).

Which volume of solution is typically administered through subcutaneous injection?

In humans general volume limits of subcutaneous injection are about 1.5 mL [36] .

What happens if a subcutaneous injection is given intramuscularly?

Subcutaneous injections can lead to localised cellulitis, granuloma formation and abscess. The COVID-19 vaccine has shown to have high efficacy if given correctly intramuscularly. Subcutaneous injection can happen inadvertently (figure 1), affecting efficacy of vaccination and potentiate local adverse events.

Do you massage after a subcutaneous injection?

Don’t aspirate after inserting the needle (to prevent tissue damage, hematoma formation, and bruising). The likelihood of injecting into a blood vessel is small. Don’t massage the site, which can damage the underlying tissue and cause the medication to be absorbed faster than intended.

What happens if a subcutaneous injection goes into the muscle?

However, subcutaneous injections can cause abscesses and granulomas. Muscle is probably spared the harmful effects of substances injected into it because of its abundant blood supply.

What should be the volume of a subcutaneous injection?

In this sense, the maximum volume generally accepted is around 1.5 ml, although volumes of up to 3 ml are well tolerated when injected in the abdomen. Injected volumes of up to 0.5-0.8 ml are not expected to increase substantially the pain produced by the needle insertion.

What’s the maximum volume of an IM injection?

Maximum vol- umes have been proposed across the various IM sites for adult patients3,12-16 (Table 1). Overall, 5 mL has been cited for adults as the maximum volume for a single IM injection, with lower maximums proposed for adult patients with less- developed or small muscle mass. 3,13,14 iNTRAMUsCUlAR iNJECTiONs.

How much pain can a subcutaneous injection cause?

Large subcutaneous injection volumes are associated with pain. In this sense, the maximum volume generally accepted is around 1.5 ml, although volumes of up to 3 ml are well tolerated when injected in the abdomen. Injected volumes of up to 0.5-0.8 ml are not expected to increase substantially the pain produced by the needle insertion.

Which is the best site for subcutaneous injection?

The upper back also can be used as a site of subcutaneous administration. The site of injection is usually rotated when injections are frequently given. The maximum amount of medication that can be subcutaneously injected is about 2 ml.