What is a drug washout?

According to the U.S. National Library of Medicine, a washout period is defined as “a period of time during a clinical study when a participant is taken off a study drug or other medication in order to eliminate the effects of the treatment.” So basically, it means a time when a lung cancer patient is not being …

What is a washout period in psychology?

A period in a clinical study during which subjects receive no treatment for the indication under study and the effects of a previous treatment are eliminated (or assumed to be eliminated).

How long wash out period?

The minimum and maximum range of wash-out in a human subject is defined between 7 and 28 days [16]. In preclinical studies, it is recommended that the wash- out period should not be long enough for changes in animal physiology to influence study outcomes [15]. This is particularly important in fast-growing ani- mals.

What does washout mean in clinical trials?

In clinical trials, a washout period describes the length of time that someone enrolled in a trial must not receive any treatment before receiving the trial’s experimental therapy.

What is a wash out procedure?

What is a Joint Wash-Out? This is a procedure carried out under anaesthetic. It is possible for a large joint to become swollen with either a collection of blood inside the joint or fluid resulting from infection. In such circumstances it is desirable to remove the blood or infected fluid.

What is a washout phase?

The phase of a clinical trial after stopping the test medication when its effects are wearing off. It is comparable to “drying out” after acute or chronic alcohol intoxication, but the washout phase varies in duration, according to the metabolic half-life of the medication.

What is a surgical washout?

Deep infections that are caught early (within several days of their onset), and those that occur within weeks of the original surgery, may sometimes be cured with a surgical washout of the joint. During this procedure, called debridement, the surgeon removes all contaminated soft tissues.

What is cleaning out a wound called?

Debridement is a procedure for treating a wound in the skin. It involves thoroughly cleaning the wound and removing all hyperkeratotic (thickened skin or callus), infected, and nonviable (necrotic or dead) tissue, foreign debris, and residual material from dressings.

What is a washout procedure?

Washout expels any loose debris through the cannula. Debridement involves using instruments to remove damaged cartilage or bone, and this is often performed at the same time as washout.

What is control in a study?

In a scientific study, a control group is used to establish a cause-and-effect relationship by isolating the effect of an independent variable. Researchers change the independent variable in the treatment group and keep it constant in the control group. Then they compare the results of these groups.

How does washout affect the angle of attack?

Washout is a design characteristic built into the wing, where the angle of attack is reduced span-wise from root to tip, typically 1° to 2°. The reduction creates a situation where the root of the wing stalls before the tip, softening the stall and allowing the ailerons to be functional deep in the stall.

How does washout reduce the effects of adverse yaw?

Washout tends to reduce the effects of adverse yaw, but only in the portions of the ailerons that are close to the zero angle of attack. Some airplanes are trimmed so there is less down-aileron travel than up travel (aileron differential). But aileron differential is a partial cure.

What does ” wash out period ” mean for healthcare?

To “wash out” simply means to remove a substance (usually a drug) from the body either naturally or through an accelerated process. Many drugs hang around for quite some time after your last dose.

How to adjust the washout effect of a watermark?

1 Double-click near the top of the page to open the header. 2 Move the cursor over the watermark until you see the four-headed arrow, and then click the watermark to select it. 3 Under Picture Tools, select Format. 4 Try selecting Recolor, Brightness, or Contrast. See More…