Does high AFP mean cancer?

Increased AFP levels may indicate the presence of cancer, most commonly liver cancer, cancer of the ovary, or germ cell tumor of the testicles. However, not every liver, ovarian, or testicular cancer will produce significant quantities of AFP.

What are the markers for liver cancer?

The three most common markers are total alpha-fetoprotein (AFP), Lens culinaris agglutinin-reactive AFP (AFP-L3) and protein induced by vitamin K absence or antagonist-II (PIVKA-II). Total AFP has the sensitivity of 60% and specificity of 90% for the detection of HCC.

How accurate is AFP test for liver cancer?

AFP had high overall accuracy, with a c-statistic of 0.87 (95%CI 0.85 – 0.89).

What is AFP normal range?

An AFP level between 10 ng/mL to 20 ng/mL is normal for adults. An extremely high level of AFP in your blood—greater than 400 ng/mL—could be a sign of liver tumors. High levels of AFP may mean other cancers, including Hodgkin disease, lymphoma, and renal cell carcinoma (kidney cancer).

How are blood tests used to diagnose liver cancer?

How are blood tests used to diagnose liver cancer? Blood tests that measure tumor markers — the levels of these substances rise in the blood if someone has a particular cancer — can aid diagnosis. Liver cancers secrete a substance called alpha fetoprotein that is normally present in fetuses but goes away at birth.

What does AFP test for?

The alpha fetoprotein test (AFP) is a blood test performed to measure, diagnose, or monitor fetal distress or fetal abnormalities. It can also detect some liver disorders and some cancers in adults.

What do tumor marker fluctuations indicate?

Tumor marker fluctuations help in evaluating the condition of cancer, even though they are usually not specific enough by themselves to provide a clear diagnosis for the presence of cancer. In any case, the fluctuations resulting in tumor markers help to determine the extent or stage of a cancer and estimate the prognosis.

What is liver carcinoma?

A liver adenocarcinoma , also known as hepatocellular carcinoma and liver cancer, is a cancer or malignancy in the liver. There are two types of liver adenocarcinoma — primary and secondary. The former is a cancer that originated in the liver.