How is murine leukemia virus transmitted?

Murine leukemia virus (MLV) is a mouse gammaretrovirus that can cause leukemia and lymphoma in mice (1–3). The virus is transmitted vertically from mother to offspring and horizontally between fighting mice (4, 5).

What is an ecotropic virus?

Generally, a virus that will only replicate in its original host species.

When was murine leukemia virus discovered?

Xenotropic murine leukemia virus-related virus (XMRV) was discovered in 2006 in a search for a viral etiology of human prostate cancer (PC).

What is Amphotropic?

Amphotropism or amphotropic indicates that a pathogen like a virus or a bacterium has a wide host range and can infect more than one species or cell culture line.

Is Mmlv a retrovirus?

MMLV retroviral vectors are derived from Moloney murine leukemia virus, which is a member of the retrovirus family.

Can I freeze retrovirus?

A: VSVG-pseudotyped retrovirus can be frozen, but it will degrade even at -80ºC. On average, each freeze/thaw cycle will result in a 2-4 fold decrease in titer. Amphotropic and ecotropic viruses are not able to handle a freeze/thaw cycle and should be used fresh.

Can XMRV infect humans?

XMRV Can Infect Human Cells Infected tissues included lymphoid organs (CD4-positive cells) as well as the prostatic epithelium and reproductive tract (Onlamoon et al., 2011). These results show that XMRV has the capability to infect humans.

Are retroviruses viruses?

​Retrovirus A retrovirus is a virus that uses RNA as its genetic material. When a retrovirus infects a cell, it makes a DNA copy of its genome that is inserted into the DNA of the host cell. There are a variety of different retroviruses that cause human diseases such as some forms of cancer and AIDS.

What type of virus is XMRV?

Xenotropic murine leukemia virus-related virus (XMRV) is a γ retrovirus that has been associated with chronic fatigue syndrome (CFS) and prostate cancer. The search for viral causes of these syndromes was reignited by the finding that RNase L activity was low in hereditary prostate cancer and some CFS patients.

What is the life cycle of RSV?

RSV can live on hard surfaces for many hours. It takes between two to eight days from the time a person is exposed to the RSV to show symptoms. Symptoms generally last three to seven days. Most children and adults recover fully in one to two weeks.