What are ketolides used for?

Ketolides (telithromycin) are derivatives of erythromycin A specifically designed for activity against bacteria responsible for community-acquired respiratory tract infections. Telithromycin is a 14-membered macrolide with a 3-keto group substitution.

What is macrolides and ketolides?

Macrolides and ketolides are two families of antibiotics that share the same mechanism of action. They bind to different bases of the peptidyl transferase center of 23S RNA.

How do ketolides work?

Ketolides work by inhibiting protein synthesis and blocking the ability of bacteria to make essential proteins required for their maintenance and survival.

What are aminoglycosides used to treat?

Aminoglycosides are used in the treatment of severe infections of the abdomen and urinary tract, as well as bacteremia and endocarditis. They are also used for prophylaxis, especially against endocarditis. Resistance is rare but increasing in frequency.

Are Ketolides broad spectrum?

They are semi-synthetic antibiotics derived from erythromycin (macrolide antibiotic) and the changes give ketolides a broader spectrum of activity.

How are ketolides different from other macrolides?

Ketolide. Ketolides are antibiotics belonging to the macrolide group. Ketolides are derived from erythromycin by substituting the cladinose sugar with a keto-group and attaching a cyclic carbamate group in the lactone ring. These modifications give ketolides much broader spectrum than other macrolides.

What kind of antibiotic is a ketolide?

Member of a class of antimicrobial agents related to macrolides. A derivative of the macrolide antibiotics, modified by the addition of a ketone to the macrolide structure. Telithromycin is a ketolide. Want to thank TFD for its existence? Tell a friend about us, add a link to this page, or visit the webmaster’s page for free fun content .

How are ketolides derived from erythromycin and cladinose?

Ketolides are derived from erythromycin by substituting the cladinose sugar with a keto-group and attaching a cyclic carbamate group in the lactone ring. These modifications give ketolides much broader spectrum than other macrolides.

Which is more powerful azithromycin or ketolides?

According to a recent study comparing the action of the classic macrolides erythromycin and azithromycin with ketolides, which are used to treat serious infections, the more powerful drugs (ketolides) were the more “leaky” in blocking the production of proteins.