Why is sublingual more effective?

One reason for selecting the sublingual route is to avoid drug destruction. Because gastric acid and intestinal and hepatic enzymes are bypassed, sublingual absorption can be more efficient overall for certain drugs than intestinal uptake. The onset of drug effect may also be quicker than with oral ingestion.

What drugs are administered sublingually?

Sublingual administration, in which a tablet or troche is allowed to dissolve completely in the oral cavity, takes advantage of the permeability of the oral epithelium and is the preferred route for a few potent lipophilic drugs, such as nitroglycerin and oxytocin, and even the commonly used oral sedative triazolam.

How fast does sublingual medicine work?

Peak blood levels of most products administered sublingually are achieved within 10‐15 minutes, which is generally much faster than when those same drugs are ingested orally. Sublingual absorption is efficient. The percent of each dose absorbed is generally higher than that achieved by means of oral ingestion.

Why is nitro given sublingually instead of orally?

Glyceryl trinitrate (or nitroglycerin) undergoes extensive hepatic presystemic metabolism when given orally, and is therefore usually given by the sublingual route, by which it is well absorbed and rapidly taken up into the circulation.

Can any drug be taken sublingually?

Almost any form of substance may be amenable to sublingual administration if it dissolves easily in saliva. Powders and aerosols may all take advantage of this method. However, a number of factors, such as pH, molecular weight, and lipid solubility, may determine whether the route is practical.

Is it OK to swallow sublingual B12?

Do not swallow a lozenge or sublingual tablet whole. Allow it to dissolve in your mouth without chewing. The sublingual tablet should be placed under your tongue. Do not crush, chew, or break an extended-release tablet.

Why are drugs given sublingually?

Sublingual administration of drug refers to the placement of drug under the tongue (Rehfeld et al., 2017). The sublingual route bypasses the first-pass metabolism and hence facilitates rapid absorption of the drug into the systemic circulation. Drug directly reaches the systemic circulation using blood vessels.

How is sublingual administration used to give medication?

Sublingual Administration is a way of giving medication through the mouth. It involves placing the drug beneath the tongue, to be absorbed and dissolved into the bloodstream through the mucous membranes. These drugs are in the form of tablets that dissolve, sprays, or films.

Where does the word sublingual come from in medicine?

Sublingual (abbreviated SL), from the Latin for “under the tongue”, refers to the pharmacological route of administration by which substances diffuse into the blood through tissues under the tongue.

Which is an example of medication in a sublingual strip?

Suboxone is an example of medication that comes in a sublingual strip. Multi-purpose tablets—Soluble tablets for either oral or sublingual (or buccal) administration, often also suitable for preparation of injections, Hydrostat (hydromorphone) and a number of brands of morphine tablets and cubes.

Why is sublingual administration better than transmucosal administration?

Because sublingual venous drainage is systemic rather than portal, hepatic first-pass elimination can be avoided. On the other hand, the transmucosal or sublingual route also offers the potential for more rapid absorption and onset of action relative to the oral route.